Publications

Retromer in Polarized Protein Transport.

Intracellular Cholesterol Trafficking and Impact in Neurodegeneration.

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy.

p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.

Dysregulation of autophagy as a common mechanism in lysosomal storage diseases.

6-Shogaol has anti-amyloidogenic activity and ameliorates Alzheimer's disease via CysLT1R-mediated inhibition of cathepsin B.

Isolation and Culturing of Rat Primary Embryonic Basal Forebrain Cholinergic Neurons (BFCNs).

Role of mammalian target of rapamycin signaling in autophagy and the neurodegenerative process using a senescence accelerated mouse-prone 8 model.

Regulation of lysosomal ion homeostasis by channels and transporters.

Methods related to studying tau fragmentation.

ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease.

Congenital Disorders of Autophagy: What a Pediatric Neurologist Should Know.

The Effects of Extracellular Serum Concentration on APP Processing in Npc1-Deficient APP-Overexpressing N2a Cells.

The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy.

Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation.

Bin1 and CD2AP polarize Aβ generation in neurons.

Interplay of pathogenic forms of human tau with different autophagic pathways.

Prostaglandin J2 promotes O-GlcNAcylation raising APP processing by α- and β-secretases: relevance to Alzheimer's disease.

Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance.

Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease.

Bin1 and CD2AP polarise the endocytic generation of beta-amyloid.

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes.

Developmental suppression of forebrain trkA receptors and attentional capacities in aging rats: A longitudinal study.

ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.

The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects.

Presence of insoluble Tau following rotenone exposure ameliorates basic pathways associated with neurodegeneration.

Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing.

Dysregulation of intracellular trafficking and endosomal sorting in Alzheimer's disease: controversies and unanswered questions.

Young Human Cholinergic Neurons Respond to Physiological Regulators and Improve Cognitive Symptoms in an Animal Model of Alzheimer's Disease.

Dendrobium nobile Lindl alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by Aβ

PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.

Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein.

Polyrotaxane-based systemic delivery of β-cyclodextrins for potentiating therapeutic efficacy in a mouse model of Niemann-Pick type C disease.

Autophagy and neuronal cell death in neurological disorders.

Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease.

Increase in cortical endocannabinoid signaling in a rat model of basal forebrain cholinergic dysfunction.

Vps35-dependent recycling of Trem2 regulates microglial function.

Striatal astrocytes engulf dopaminergic debris in Parkinson's disease: A study in an animal model.

ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease.

Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease.

Nerve growth factor released from collagen scaffolds protects axotomized cholinergic neurons of the basal nucleus of Meynert in organotypic brain slices.

Autophagy, amyloidogenesis and Alzheimer disease.

Progesterone suppresses Aβ

C-terminal truncation of GSK-3β enhances its dephosphorylation by PP2A.

Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+‑calpain‑p25‑CDK5 pathway in HT22 cells.

Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors.

Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis.

C-myb Plays an Essential Role in the Protective Function of IGF-1 on Cytotoxicity Induced by Aβ

Vitamin D Combined with Resveratrol Prevents Cognitive Decline in SAMP8 Mice.

Clearing truncated tau protein restores neuronal function and prevents microglia activation in tauopathy mice.

Endo-lysosomal dysfunction in neurodegenerative diseases: opinion on current progress and future direction in the use of exosomes as biomarkers.

TRIM22 facilitates autophagosome-lysosome fusion by mediating the association of GABARAPs and PLEKHM1.

Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle.

Overexpression of let-7a increases neurotoxicity in a PC12 cell model of Alzheimer's disease via regulating autophagy.

Endolysosome and Autolysosome Dysfunction in Alzheimer's Disease: Where Intracellular and Extracellular Meet.

Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice.

Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2.

Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms.

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies.

Cathepsin D as a therapeutic target in Alzheimer's disease.

Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice.

Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer's disease pathogenesis.

Alzheimer's disease genes and autophagy.

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The normal and pathologic roles of the Alzheimer's β-secretase, BACE1.

Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model.

ApoE4 disrupts intracellular trafficking and iron homeostasis in a reproducible iPSC-based model of human brain endothelial cells.

Electroacupuncture regulates Rab5a-mediating NGF transduction to improve learning and memory ability in the early stage of AD mice.

Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice.

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.

A Recent Update on Pathophysiology and Therapeutic Interventions of Alzheimer's Disease.

Resveratrol Attenuates CSF Markers of Neurodegeneration and Neuroinflammation in Individuals with Alzheimer's Disease.

The fate of the brain cholinergic neurons in neurodegenerative diseases.

Presenilins and γ-Secretase in Membrane Proteostasis.

Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?

Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction.

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease.

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease.

Endolysosome and autophagy dysfunction in Alzheimer disease.

TRPV1 regulates ApoE4-disrupted intracellular lipid homeostasis and decreases synaptic phagocytosis by microglia.

Synthesized Aβ42 Caused Intracellular Oxidative Damage, Leading to Cell Death, via Lysosome Rupture.

SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration.

Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders.

A SPLICS reporter reveals [Formula: see text]-synuclein regulation of lysosome-mitochondria contacts which affects TFEB nuclear translocation.

Aβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways.

Critical role of ROCK1 in AD pathogenesis via controlling lysosomal biogenesis and acidification.

Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.

Proteomic analysis links truncated tau to lysosome motility, autophagy, and endo-lysosomal dysfunction.

A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Barrier and Selectively Delivering siRNA to Neurons for Alzheimer's Disease Treatment.

Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?

Pimozide reduces toxic forms of tau in TauC3 mice via 5' adenosine monophosphate-activated protein kinase-mediated autophagy.

Alzheimer's disease-related amyloid-β

Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma.

Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer's disease.

OAB-14 Effectively Ameliorates the Dysfunction of the Endosomal-Autophagic-Lysosomal Pathway in APP/PS1 Transgenic Mice.

Exploring the potential role of rab5 protein in endo-lysosomal impairment in Alzheimer's disease.

Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice.

Autophagy, aging, and age-related neurodegeneration.

The Endosomal-Lysosomal Pathway Is Dysregulated by