Publication
Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease.
Kiprowska Magdalena J, Stepanova Anna, Todaro Dustin R, Galkin Alexander, Haas Arthur, Wilson Scott M, Figueiredo-Pereira Maria E
Biochimica et biophysica acta. Molecular basis of disease2017DOI: 10.1016/j.bbadis.2017.03.017PMID 28372990
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Abstract
In Alzheimer's disease proteasome activity is reportedly downregulated, thus increasing it could be therapeutically beneficial. The proteasome-associated deubiquitinase USP14 disassembles polyubiquitin-chains, potentially delaying proteasome-dependent protein degradation. We assessed the protective efficacy of inhibiting or downregulating USP14 in rat and mouse (Usp14
MeSH Terms
Alzheimer DiseaseAnimalsCerebral CortexDose-Response Relationship, DrugElectron Transport Complex IMiceMitochondriaNeuronsNeurotoxicity SyndromesPyrrolesPyrrolidinesRatsRats, Sprague-DawleyUbiquitin ThiolesteraseUbiquitinationtau Proteins