Publication
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.
Wang Chao, Xiong Monica, Gratuze Maud, Bao Xin, Shi Yang, Andhey Prabhakar Sairam, Manis Melissa, Schroeder Caitlin, Yin Zhuoran, Madore Charlotte, Butovsky Oleg, Artyomov Maxim, Ulrich Jason D, Holtzman David M
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Abstract
The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer's disease and directly influences tauopathy and tau-mediated neurodegeneration. ApoE4 has strong deleterious effects on both parameters. In the brain, apoE is produced and secreted primarily by astrocytes and by activated microglia. The cell-specific role of each form of apoE in the setting of neurodegeneration has not been determined. We generated P301S Tau/Aldh1l1-CreERT2/apoE3
MeSH Terms
AnimalsApolipoprotein E4ApoptosisAstrocytesHumansMiceMice, Inbred C57BLMicrogliaPhagocytosisSynapsesTauopathiesTranscriptometau Proteins