Publication
Dendrobium nobile Lindl alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by Aβ
Li Li-Sheng, Lu Yan-Liu, Nie Jing, Xu Yun-Yan, Zhang Wei, Yang Wen-Jin, Gong Qi-Hai, Lu Yuan-Fu, Lu Yang, Shi Jing-Shan
Abstract
AIMS: Axonal degeneration is a pathological symbol in the early stage of Alzheimer's disease (AD), which can be triggered by amyloid-β (Aβ) peptide deposition. Growing evidence indicates that deficit of autophagy eventually leads to the axonal degeneration. Our previous studies have shown that Dendrobium nobile Lindl alkaloid (DNLA) had protective effect on neuron impairment in vivo and in vitro; however, the underlying mechanisms is still unclear. METHODS: We exposed cultured hippocampus neurons to Aβ RESULTS: DNLA pretreatment significantly inhibited axonal degeneration induced by Aβ CONCLUSIONS: DNLA prevents Aβ