Publication
Alzheimer's disease-related amyloid-β
Tavares R S, Martins S, Almeida-Santos T, Sousa A P, Ramalho-Santos J, da Cruz E Silva O A
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Abstract
Characteristically identified as the main component of senile plaques present in patients suffering from Alzheimer's disease, Aβ has been detected in human testis and reproductive fluids, but its effect on spermatozoa has not been addressed. The present study evaluated whether the most toxic and aggregant amyloid precursor protein (APP)-proteolytic product, amyloid-β
MeSH Terms
AcrosomeAlzheimer DiseaseAmyloid beta-PeptidesCalciumCell SurvivalHumansIntracellular SpaceMaleMitochondriaPhosphorylationPhosphotyrosineSperm MotilitySpermatozoa