Publication
C-myb Plays an Essential Role in the Protective Function of IGF-1 on Cytotoxicity Induced by Aβ
Zhang Jingyu, Shu Yongwei, Qu Yang, Zhang Lina, Chu Tingting, Zheng Yonghui, Zhao Hong
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Abstract
There have been numerous reports about neurodegenerative diseases, including Alzheimer's disease. Nevertheless, the molecules responsible for the neurodegeneration in Alzheimer's disease are basically unknown. Recent findings indicate that the cellular myeloblastosis (c-myb) regulates neural progenitor cell proliferation. In the current study, the function of insulin-like growth factor-1 (IGF-1) against cell toxicity in SH-SY5Y cells induced by β-amyloid 25-35 (Aβ
MeSH Terms
Amyloid beta-PeptidesApoptosisCalpainCell Line, TumorHumansInsulin-Like Growth Factor INeuronsPeptide FragmentsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-mybSignal Transductiontau Proteins