Publication
LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease.
Heckmann Bradlee L, Teubner Brett J W, Tummers Bart, Boada-Romero Emilio, Harris Lacie, Yang Mao, Guy Clifford S, Zakharenko Stanislav S, Green Douglas R
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Abstract
The expression of some proteins in the autophagy pathway declines with age, which may impact neurodegeneration in diseases, including Alzheimer's Disease. We have identified a novel non-canonical function of several autophagy proteins in the conjugation of LC3 to Rab5
MeSH Terms
Alzheimer DiseaseAmyloid beta-PeptidesAnimalsAutophagy-Related Protein 5Autophagy-Related ProteinsCD36 AntigensCytokinesDisease Models, AnimalEndocytosisHippocampusIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsMiceMice, TransgenicMicrogliaMicrotubule-Associated ProteinsRAW 264.7 CellsReceptors, ImmunologicToll-Like Receptor 4