Large ribosomal subunit protein eL43

RPL37A encodes a large ribosomal subunit protein (eL43) that functions as a structural component of the 60S ribosome, participating in protein synthesis (UniProt: P61513). The protein is a small, conserved component of the translational machinery expressed broadly across human tissues.

In Alzheimer's disease, RPL37A is upregulated in post-mortem AD brain tissue relative to age-matched controls according to quantitative proteomics analysis (Chaparral AD proteomics). The protein showed a mean log2 fold-change of +0.29 in human post-mortem AD brain versus controls, measured via tandem mass spectrometry across subcellular fractions. This modest elevation was detected in one subcellular fraction during differential abundance analysis.

The biological significance of elevated ribosomal protein levels in AD brain remains to be clarified, though altered protein synthesis capacity and ribosomal dysfunction have been implicated in neurodegeneration. No other curated disease associations are documented in the UniProt record for this protein.