Large ribosomal subunit protein eL28

RPL28 (large ribosomal subunit protein eL28) is a structural component of the large ribosomal subunit and participates in protein synthesis within the cell (UniProt: P46779). As a ribosomal protein, it is essential for translational function across all tissues and cell types.

No specific tissue restriction or UniProt-curated disease associations are documented for RPL28. The protein functions broadly in cellular protein synthesis machinery without noted pathogenic mutations or disease links in the reference database.

In Alzheimer's Disease, RPL28 is significantly upregulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of +0.46 (Chaparral AD proteomics). This upregulation was detected across subcellular fractions in TMT-labeled quantitative proteomics, suggesting increased ribosomal protein abundance in the AD brain proteome, potentially reflecting altered translational capacity or compensatory responses in neurodegeneration.