Large ribosomal subunit protein uL30

RPL7 (large ribosomal subunit protein uL30) is a structural component of the large ribosomal subunit that participates in protein synthesis (UniProt: P18124). It binds G-rich RNA structures in 28S rRNA and mRNAs, and plays a regulatory role in the translation apparatus by inhibiting cell-free translation (UniProt: P18124).

The protein is a core constituent of the ribosomal translation machinery, which is distributed across subcellular compartments. UniProt lists no primary disease associations for RPL7 (UniProt: P18124).

RPL7 is curated as relevant to Alzheimer's Disease in this dataset (Chaparral AD proteomics). In post-mortem AD brain tissue analyzed by TMT quantitative proteomics across four subcellular fractions, RPL7 shows ambiguous directional change (mean log2FC: −0.09) relative to age-matched controls, indicating minimal and inconsistent variation across fractions. This near-neutral proteome signature suggests RPL7 abundance is largely preserved in AD brain despite the disease's profound effects on protein synthesis and neuronal viability.