Large ribosomal subunit protein uL10

RPLP0 encodes the large ribosomal subunit protein uL10 (also designated P0), a structural and functional component of the ribosomal 60S subunit. It is the eukaryotic functional homolog of bacterial L10 protein and participates in translation catalysis and ribosome assembly (UniProt: P05388).

RPLP0 is expressed broadly across tissues as a core ribosomal constituent required for protein synthesis. No disease associations are documented in UniProt curated records. However, dysregulation of ribosomal biogenesis and translation have been implicated in various neurodegenerative contexts.

RPLP0 is tagged as Alzheimer's Disease-relevant in this dataset, though evidence for differential regulation is ambiguous. Across the analyzed subcellular fractions (P2, P3, S2, S3) from post-mortem AD brain relative to age-matched controls, RPLP0 shows minimal mean log2 fold-change (−0.0199), indicating no consistent up- or down-regulation by TMT-labeled proteomics (Chaparral AD proteomics). The two-fraction representation suggests variable changes across subcellular compartments.