Large ribosomal subunit protein eL31

RPL31 encodes a large ribosomal subunit protein (eL31) that functions as a structural component of the ribosome, the cellular machinery responsible for protein synthesis (UniProt: P62899). The protein is a constituent of the 60S ribosomal subunit and participates in translation initiation and elongation across all cell types. No disease associations are documented in UniProt for this protein.

RPL31 shows reduced abundance in Alzheimer's disease brain tissue. Quantitative proteomic analysis of post-mortem AD brain compared to age-matched controls revealed a mean log2 fold-change of −0.47 (Chaparral AD proteomics), indicating consistent downregulation. This decrease was observed across one subcellular fraction in a TMT-labeled, data-dependent acquisition mass spectrometry study spanning four cellular compartments. The functional significance of reduced ribosomal protein levels in AD neuropathology remains to be elucidated, though ribosomal dysfunction and translation impairment have been implicated in neurodegeneration.