Large ribosomal subunit protein eL27

RPL27 encodes the large ribosomal subunit protein eL27, a structural component essential for ribosome assembly and function. It is required for proper processing and maturation of ribosomal RNAs (28S and 5.8S rRNAs) and participates in large subunit biogenesis (UniProt: P61353).

The protein is ubiquitously expressed across tissues as part of the core translational machinery. UniProt annotations associate RPL27 with Diamond-Blackfan anemia 16 (DBA16), a rare autosomal dominant disorder affecting erythropoiesis and characterized by macrocytic anemia and developmental anomalies.

In Alzheimer's Disease, RPL27 is downregulated in post-mortem AD brain tissue relative to age-matched controls (Chaparral AD proteomics). Quantitative proteomics using TMT labeling across subcellular fractions detected a mean log2 fold-change of −0.38, suggesting reduced ribosomal protein abundance in AD pathology and potentially implicating altered protein synthesis capacity as a disease-relevant mechanism.