Large ribosomal subunit protein uL15

RPL27A encodes large ribosomal subunit protein uL15, a structural component of the large ribosomal subunit (UniProt: P46776). This protein participates in the ribosomal machinery responsible for cellular protein synthesis, functioning as part of the ribonucleoprotein complex that translates mRNA into proteins.

RPL27A is a canonical ribosomal protein with no disease associations documented in UniProt. However, it localizes broadly across tissues where protein translation is active, including the central nervous system.

In Alzheimer's Disease, RPL27A shows increased abundance in post-mortem AD brain tissue compared to age-matched controls (mean log2 fold-change: 0.7286; Chaparral AD proteomics). This upregulation was detected via TMT-labeled tandem mass spectrometry across multiple subcellular fractions (P2, P3, S2, S3) from human post-mortem brain. The elevation of ribosomal proteins in AD brain tissue may reflect compensatory protein synthesis responses or altered translational capacity in the diseased state, though functional consequences remain to be determined.