Large ribosomal subunit protein eL29

RPL29 encodes the large ribosomal subunit protein eL29, a structural component of the ribosome involved in protein synthesis (UniProt: P47914). The protein is a core constituent of the large ribosomal subunit and plays a fundamental role in translation, the process by which cells synthesize proteins from mRNA templates.

RPL29 is ubiquitously expressed across tissues as part of the essential translation machinery. UniProt reports no specific disease associations in its curated knowledge base for this protein.

In Alzheimer's Disease, RPL29 shows increased abundance in post-mortem AD brain tissue relative to age-matched controls (Chaparral AD proteomics). The protein was upregulated with a mean log2 fold-change of 0.346 across subcellular fractions in a TMT-labeled proteomics study comparing four subcellular compartments (P2, P3, S2, S3) in human post-mortem brain. This elevation may reflect alterations in translational capacity or ribosomal composition in the AD-affected brain.