Small ribosomal subunit protein eS25

RPS25 encodes the small ribosomal subunit protein eS25, a 125-amino-acid component of the 40S ribosomal subunit involved in protein synthesis (UniProt: P62851). The protein localizes to the ribosome, where it participates in the fundamental cellular process of translation.

RPS25 is widely expressed as a core ribosomal protein and is essential for translation machinery function. No inherited disease associations have been catalogued in UniProt for this gene. However, ribosomal dysfunction and altered protein synthesis have been implicated in multiple pathological contexts.

In Alzheimer's disease, RPS25 is upregulated in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). The mean log2 fold-change is 0.308 across a single subcellular fraction in a TMT-labeled proteomic study of four subcellular compartments (P2, P3, S2, S3). This modest elevation suggests a compensatory or disease-associated shift in ribosomal protein composition in AD brain.