Coronin-1A

Coronin-1A (CORO1A) is a 461-amino acid cytoskeletal protein that plays a crucial role in regulating plasma membrane dynamics and cell motility (UniProt: P31146). It functions in both large-scale membrane invagination and the formation of membrane protrusions involved in cell locomotion. In mycobacteria-infected cells, Coronin-1A retention on phagosomal membranes prevents fusion with lysosomes, suggesting roles in innate immunity and intracellular pathogen handling.

Coronin-1A is associated with Immunodeficiency 8 with lymphoproliferation (IMD8), a disease characterized by CD4+ T-cell lymphopenia and recurrent infections (UniProt: P31146). This genetic association underscores its importance in immune cell function and T-cell homeostasis.

Coronin-1A exhibits ambiguous regulation in Alzheimer's Disease, with conflicting direction across subcellular fractions in post-mortem AD brain tissue versus age-matched controls (mean log2FC −0.58 across 2 of 4 TMT-labeled fractions) (Chaparral AD proteomics). The inconsistency across fractions suggests compartment-specific dysregulation rather than global changes in this protein during AD pathogenesis.