Obg-like ATPase 1

OLA1 (Obg-like ATPase 1) is a 396-amino acid nucleotide hydrolase that preferentially hydrolyzes ATP, with lower efficiency for GTP hydrolysis (UniProt: Q9NTK5). The protein belongs to the AAA+ ATPase family and functions as a GTPase with roles in cellular stress responses and protein quality control mechanisms.

OLA1 is widely expressed across tissues and participates in nucleotide-dependent signaling pathways. No specific disease associations are documented in UniProt for this protein.

OLA1 has been curated as relevant to Alzheimer's Disease. In quantitative proteomics of post-mortem AD brain tissue (TMT-labeled, four subcellular fractions—P2, P3, S2, S3—analyzed by data-dependent acquisition), OLA1 shows ambiguous direction of change across fractions with a mean log2 fold-change of 0.1857 relative to age-matched controls (Chaparral AD proteomics). The differential detection across subcellular compartments suggests possible redistribution rather than global abundance change in AD brain.