protein
Coronin-1B
Coronin-1B (CORO1B) is a 489-amino-acid protein that regulates leading edge dynamics and cell motility in fibroblasts and may participate in cytokinesis and signal transduction (UniProt: Q9BR76).
The protein functions in actin dynamics and cellular migration pathways. No specific tissue or pathway associations related to disease are documented in UniProt.
In Alzheimer's Disease, Coronin-1B shows increased abundance in post-mortem AD brain tissue compared to age-matched controls. Quantitative proteomics data from human AD brain (TMT-labeled, 4 subcellular fractions) demonstrates upregulation with a mean log2 fold-change of 1.13 (Chaparral AD proteomics), suggesting potential involvement in AD-associated cellular alterations affecting motility or cytoskeletal dynamics.
Generated from the curated entity record below. May contain errors — verify against source links.
Interaction partners · context, not scored
Published · Affinity capture-MS (HEK293T) · Wang et al., Science 2026 · 2 partners
3D Structure
Structure predicted by AlphaFold 2 · alphafold.ebi.ac.uk· Confidence: Confident
Sources
Last updated 10/3/2026, 4:57:13 AM