Flotillin-1

Flotillin-1 (FLOT1) is a membrane-associated scaffolding protein that functions in the formation and organization of caveolae and caveolae-like vesicles within the plasma membrane (UniProt: O75955). The protein plays a structural role in organizing lipid raft microdomains, which are important for membrane trafficking and cell signaling.

Flotillin-1 is widely expressed across tissues and participates in vesicular transport and endocytic pathways. No primary disease associations are documented in UniProt for this protein; however, it has been identified in proteomic studies of neurodegenerative conditions.

In Alzheimer's disease, Flotillin-1 is downregulated in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). Across two subcellular fractions analyzed in a TMT-labeled quantitative proteomics experiment, the protein showed a mean log2 fold-change of −0.44, indicating modest but consistent reduction. This downregulation may reflect disruptions in membrane organization and vesicular trafficking pathways implicated in AD pathogenesis.