Small ribosomal subunit protein eS8

RPS8 (small ribosomal subunit protein eS8) is a 24 kDa component of the small ribosomal subunit (UniProt: P62241). It participates in ribosomal assembly and function within the nucleolus as part of the small subunit (SSU) processome, where it facilitates pre-rRNA processing, modification, and the coordinated work of ribosome biogenesis factors to generate mature ribosomal subunits (UniProt: P62241).

RPS8 is a structural and catalytic component essential for protein synthesis, with no known disease associations catalogued in UniProt. The protein is ubiquitously expressed across tissues where ribosome biogenesis is active, including the brain.

In Alzheimer's Disease, RPS8 is upregulated in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). The mean log2 fold-change is +0.2363 across the analysed subcellular fractions from TMT-labeled, data-dependent acquisition proteomics. This modest elevation may reflect altered translation capacity or compensatory ribosomal protein synthesis in the context of neurodegeneration.