Small ribosomal subunit protein uS10

RPS20 encodes small ribosomal subunit protein uS10, a structural component of the 40S ribosomal subunit that participates in protein synthesis, a fundamental cellular function conserved across eukaryotes (UniProt: P60866).

The protein is a constituent of the small ribosomal subunit, which assembles with the large subunit to form the functional ribosome responsible for translation. RPS20 has no annotated disease associations in the UniProt knowledge base.

RPS20 is curated as Alzheimer's Disease-relevant in this dataset. Quantitative proteomic analysis of post-mortem AD brain tissue revealed that RPS20 is downregulated relative to age-matched controls (mean log2 fold-change = −0.31), suggesting reduced small ribosomal subunit protein abundance in the diseased state (Chaparral AD proteomics). This finding derives from TMT-based quantitation across multiple subcellular fractions, though the direction is consistent across the analyzed compartments.