CAP-Gly domain-containing linker protein 1

CAP-Gly domain-containing linker protein 1 (CLIP1) is a microtubule-binding protein that regulates microtubule dynamics and intracellular vesicle transport. It binds the plus end of microtubules to promote growth and bundling, and links cytoplasmic vesicles to the microtubule cytoskeleton, facilitating endosome trafficking and macropinocytosis (UniProt: P30622).

CLIP1 functions in intracellular trafficking pathways dependent on the microtubule cytoskeleton. No disease associations are listed in the UniProt record for this protein.

In Alzheimer's disease, CLIP1 is upregulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of 0.81 across subcellular fractions in TMT-labeled proteomics analysis (Chaparral AD proteomics). This elevation may reflect compensatory responses or pathological changes in the vesicular and cytoskeletal dynamics that are disrupted in neurodegeneration.