Ras GTPase-activating-like protein IQGAP1

IQGAP1 is a Ras GTPase-activating-like protein that regulates actin cytoskeleton dynamics and assembly (UniProt: P46940). It interacts with ILK and cooperates with DIAPH1 to stabilize microtubules and facilitate caveolin insertion at the plasma membrane. The protein binds activated CDC42 without stimulating its GTPase activity and associates with calmodulin, with potential roles in neurite outgrowth and cell cycle regulation.

IQGAP1 is widely expressed and functions as a key regulator of cytoskeletal organization across diverse cellular contexts. No disease associations are documented in UniProt for this protein.

IQGAP1 shows increased abundance in Alzheimer's disease brain tissue compared to age-matched controls (Chaparral AD proteomics). Analysis of post-mortem AD brain across four subcellular fractions using TMT-labeled mass spectrometry revealed upregulation with a mean log2 fold-change of 0.68, suggesting a consistent elevation in the disease state. This upregulation may relate to cytoskeletal reorganization or compensatory responses in the AD pathogenic process.