Nuclear migration protein nudC

Nuclear migration protein nudC (NUDC) is a 331-amino acid cytoplasmic protein essential for cell division and neuronal development (UniProt: Q9Y266). It plays critical roles in neurogenesis and neuronal migration, and is necessary for proper mitotic spindle formation, chromosome segregation during mitosis, and cytokinesis. These functions are particularly important for maintaining cellular proliferation and coordinating neuronal organization.

NUDC is expressed in neural tissues and functions within pathways governing cell cycle progression and cytoskeletal dynamics. No baseline disease associations are documented in the UniProt record (UniProt: Q9Y266).

NUDC shows increased abundance in Alzheimer's Disease brain tissue relative to age-matched controls. In human post-mortem AD brain analyzed via TMT-labeled proteomics across multiple subcellular fractions, NUDC was upregulated with a mean log2 fold-change of 0.726 (Chaparral AD proteomics). This elevation may reflect altered cell cycle activity or compensatory mechanisms in AD-affected neurons, though functional significance requires further investigation.