Isoform 3 of CLIP-associating protein 2

CLASP2 (CLIP-associating protein 2) isoform 3 is a 165 kDa protein encoded by the CLASP2 gene in humans (UniProt: O75122-3). While specific molecular function annotations are not detailed in the available data, CLASP proteins are known to regulate microtubule dynamics and are involved in cytoskeletal organization at the cell cortex.

The protein was detected in post-mortem human brain tissue across subcellular fractions in a comparative proteomics study of Alzheimer's Disease versus age-matched controls. No additional tissue-specific or pathway associations are documented in the UniProt record.

CLASP2 isoform 3 shows reduced abundance in AD brain tissue, with a mean log2 fold-change of −0.82 (Chaparral AD proteomics). This down-regulation was observed in a TMT-labeled quantitative proteomics experiment analyzing four subcellular fractions from post-mortem AD brain samples, suggesting potential involvement of microtubule-associated processes in AD pathology.