Isoform 2 of Tropomyosin beta chain

Tropomyosin beta chain (TPM2) is a cytoskeletal protein that regulates actin filament dynamics and muscle contraction. Isoform 2 is a 284 amino acid variant (UniProt: P07951-2) involved in stabilizing and modulating the mechanical properties of the actin cytoskeleton across diverse cell types.

TPM2 is widely expressed in skeletal, cardiac, and smooth muscle tissues, as well as non-muscle cells where it participates in cytoskeletal organization and contractility. The protein has established roles in neuromuscular function and muscle development.

In Alzheimer's Disease, TPM2 isoform 2 shows a consistent upregulation pattern in post-mortem AD brain tissue compared to age-matched controls (mean log2 fold-change +1.08; Chaparral AD proteomics). This elevation was detected across 2 of 4 examined subcellular fractions in a TMT-labeled quantitative proteomics study, suggesting altered actin dynamics or cytoskeletal remodeling may contribute to AD pathology.