Tropomodulin-3

Tropomodulin-3 (TMOD3) is an actin-binding protein that regulates actin filament dynamics by blocking elongation and depolymerization at the pointed end (UniProt: Q9NYL9). Through its interaction with tropomyosin, it helps establish the geometry of the membrane skeleton by promoting short actin protofilament formation.

The protein functions in cytoskeletal organization and is expressed across human tissues. UniProt records no primary disease associations for TMOD3, though its role in actin dynamics suggests potential relevance to neuronal morphology and synaptic function.

In Alzheimer's Disease, TMOD3 shows increased abundance in post-mortem AD brain tissue compared to age-matched controls (mean log2 fold-change: 0.49; Chaparral AD proteomics). This upregulation was detected via quantitative proteomics across subcellular fractions, suggesting altered actin cytoskeleton remodeling may accompany AD pathology.