Myosin light chain 6B

Myosin light chain 6B (MYL6B) is a regulatory light chain component of myosin that does not bind calcium (UniProt: P14649). It functions as a structural and regulatory subunit within myosin complexes, which are central to cellular motility and muscle contraction.

MYL6B is expressed across tissues where myosin-dependent processes occur. No specific disease associations are documented in UniProt, though the protein's role in cytoskeletal dynamics suggests potential relevance to neurodegenerative processes affecting cellular integrity.

In Alzheimer's Disease, MYL6B shows reduced abundance in post-mortem AD brain tissue compared to age-matched controls (mean log2 fold-change: −0.41; Chaparral AD proteomics). This downregulation was detected via TMT-labeled proteomics across four subcellular fractions from human brain homogenates, suggesting decreased myosin-associated regulatory capacity in AD pathology.