Transgelin

Transgelin (TAGLN) is a 22.6 kDa actin cross-linking and gelling protein involved in calcium-dependent interactions that regulate contractile properties and cellular senescence (UniProt: Q01995). The protein functions as an actin-binding molecule capable of modulating cell contractility through calcium signaling, with potential relevance to age-related cellular changes.

In the context of neurodegeneration, transgelin's role in actin cytoskeleton dynamics and senescence pathways situates it within cellular stress response mechanisms. No constitutive disease association is documented in UniProt; however, the protein has been detected in post-mortem brain tissue analysis.

Transgelin shows increased abundance in Alzheimer's disease brain tissue relative to age-matched controls (Chaparral AD proteomics). Analysis of human post-mortem AD brain tissue using TMT-labeled quantitative proteomics across four subcellular fractions revealed upregulation with a mean log2 fold-change of 1.29, consistent with enhanced expression in the AD brain proteome. This elevation may reflect cellular stress responses or actin remodeling associated with neurodegeneration.