Alpha-adducin

Alpha-adducin (ADD1) is a membrane-cytoskeleton-associated protein that promotes assembly of the spectrin-actin network and binds calmodulin (UniProt: P35611). It functions as a structural regulator linking membrane and cytoplasmic components in cells.

Alpha-adducin is widely expressed across tissues and participates in cytoskeletal organization. No disease associations are documented in UniProt's curated database for this protein.

In Alzheimer's disease, alpha-adducin is significantly upregulated in post-mortem AD brain tissue relative to age-matched controls (Chaparral AD proteomics). The protein showed a mean log2 fold-change of 0.87 across subcellular fractions in human post-mortem AD brain analyzed by TMT-labeled proteomics. This upregulation may reflect compensatory cytoskeletal remodeling or structural reorganization associated with AD pathology.