protein
Alpha-adducin
Gene
ADD1
Organism
Homo sapiens(9606)
Length
737 aa
Mass
80,955 Da
Alpha-adducin (ADD1) is a membrane-cytoskeleton-associated protein that promotes assembly of the spectrin-actin network and binds calmodulin (UniProt: P35611). It functions as a structural regulator linking membrane and cytoplasmic components in cells.
Alpha-adducin is widely expressed across tissues and participates in cytoskeletal organization. No disease associations are documented in UniProt's curated database for this protein.
In Alzheimer's disease, alpha-adducin is significantly upregulated in post-mortem AD brain tissue relative to age-matched controls (Chaparral AD proteomics). The protein showed a mean log2 fold-change of 0.87 across subcellular fractions in human post-mortem AD brain analyzed by TMT-labeled proteomics. This upregulation may reflect compensatory cytoskeletal remodeling or structural reorganization associated with AD pathology.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
+0.872
P2
not detected
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: +0.8718 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin
Sources
Last updated 5/8/2026, 6:36:57 AM