Twinfilin-2

Twinfilin-2 (TWF2) is an actin-binding protein that regulates actin dynamics by sequestering G-actin monomers and capping barbed ends of filaments (UniProt: Q6IBS0). These activities control cellular motility and morphological processes. The protein plays important roles in clathrin-mediated endocytosis and organelle distribution, and may contribute to stereocilia organization in sensory cells.

TWF2 is expressed across human tissues with molecular functions centered on cytoskeletal regulation. No baseline disease associations are documented in UniProt.

In Alzheimer's disease, TWF2 is significantly down-regulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of −0.692 in human post-mortem samples analyzed by TMT-labeled quantitative proteomics across subcellular fractions (Chaparral AD proteomics). This down-regulation may reflect altered endocytic dynamics or cytoskeletal remodeling associated with AD neurodegeneration.