protein
Beta-adducin
Gene
ADD2
Organism
Homo sapiens(9606)
Length
726 aa
Mass
80,854 Da
Beta-adducin (ADD2) is a membrane-cytoskeleton-associated protein that plays a structural role in organizing the spectrin-actin network at the plasma membrane (UniProt: P35612). It binds to the glucose transporter SLC2A1/GLUT1 and calmodulin, potentially linking the cytoskeletal framework to membrane receptors.
The protein is expressed as a 727-amino-acid, ~81 kDa polypeptide and functions prominently in maintaining cellular architecture through protein–protein interactions (UniProt: P35612). No explicit disease associations are documented in the UniProt record for this entry.
Beta-adducin shows increased abundance in Alzheimer's disease brain tissue. In a comparative proteomics study of post-mortem AD brain versus age-matched controls using TMT-labeled quantification across four subcellular fractions, ADD2 was upregulated with a mean log2 fold-change of +0.39 (Chaparral AD proteomics). This elevation may reflect compensatory cytoskeletal remodeling or altered membrane organization in response to AD pathology.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
+0.390
P2
not detected
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: +0.3896 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit
Sources
Last updated 5/8/2026, 6:36:55 AM