Beta-adducin

Beta-adducin (ADD2) is a membrane-cytoskeleton-associated protein that plays a structural role in organizing the spectrin-actin network at the plasma membrane (UniProt: P35612). It binds to the glucose transporter SLC2A1/GLUT1 and calmodulin, potentially linking the cytoskeletal framework to membrane receptors.

The protein is expressed as a 727-amino-acid, ~81 kDa polypeptide and functions prominently in maintaining cellular architecture through protein–protein interactions (UniProt: P35612). No explicit disease associations are documented in the UniProt record for this entry.

Beta-adducin shows increased abundance in Alzheimer's disease brain tissue. In a comparative proteomics study of post-mortem AD brain versus age-matched controls using TMT-labeled quantification across four subcellular fractions, ADD2 was upregulated with a mean log2 fold-change of +0.39 (Chaparral AD proteomics). This elevation may reflect compensatory cytoskeletal remodeling or altered membrane organization in response to AD pathology.