EH domain-containing protein 1

EHD1 (EH domain-containing protein 1) is an ATP- and membrane-binding protein that regulates membrane reorganization and vesiculation through ATP hydrolysis (UniProt: Q9H4M9). It functions in early endocytic membrane fusion and recycling endosome trafficking, and plays roles in neurite outgrowth, myoblast fusion, and cilium biogenesis by recruiting SNARE components and transition zone proteins (UniProt: Q9H4M9).

In neuronal contexts, EHD1 is involved in retrograde dendritic transport of endocytosed BACE1 and sorting to axons, implicating it in APP processing pathways relevant to neurodegeneration (UniProt: Q9H4M9). The protein localizes to endosomal membranes upon nerve growth factor stimulation.

EHD1 is curated as upregulated in Alzheimer's disease (Chaparral AD proteomics), with a mean log2 fold-change of 0.21 in human post-mortem AD brain versus age-matched controls across subcellular fractions. This elevation may reflect altered endocytic trafficking and APP processing in the AD brain, linking EHD1 to amyloid-beta metabolism and neurodegeneration pathways.