EH domain-binding protein 1

EH domain-binding protein 1 (EHBP1) is a 1231-amino-acid protein that mediates connections between clathrin-dependent endocytosis and the actin cytoskeleton (UniProt: Q8NDI1). It functions as a Rab effector in vesicle trafficking and is required for insulin-responsive glucose transporter recycling in adipocytes, indicating roles in both cytoskeletal dynamics and membrane transport.

EHBP1 is primarily documented in the context of hereditary prostate cancer (HPC12, MIM 611868), though its broader involvement in endocytic and trafficking pathways suggests relevance to multiple cellular processes (UniProt: Q8NDI1). The protein's actin-regulatory functions position it within cellular mechanisms governing morphogenesis and vesicular homeostasis.

In Alzheimer's disease, EHBP1 is downregulated in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics), with a mean log2 fold-change of −0.40 across subcellular fractions in a TMT-labeled proteomics study. This downregulation may reflect altered endocytic capacity or compromised cytoskeletal remodeling in AD pathophysiology, though the biological consequence remains to be determined.