Large ribosomal subunit protein uL1

RPL10A encodes large ribosomal subunit protein uL1, a core component of the 60S ribosomal subunit involved in cellular protein synthesis (UniProt: P62906). The protein is part of the large ribonucleoprotein complex responsible for translating mRNA into proteins across all cell types.

RPL10A is ubiquitously expressed as a structural ribosomal protein. No disease associations are documented in UniProt for this gene. However, ribosomal dysfunction and impaired protein translation have been implicated broadly in neurodegenerative processes.

In Alzheimer's disease, RPL10A shows reduced abundance in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). The protein is significantly downregulated with a mean log2 fold-change of −0.52 across the measured subcellular fractions. This downregulation of ribosomal components may reflect compromised translational capacity in AD-affected neurons, potentially contributing to protein synthesis deficits observed in the disease.