Peroxiredoxin-2

Peroxiredoxin-2 (PRDX2) is a thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, protecting cells against oxidative stress (UniProt: P32119). The protein functions as both a detoxifying enzyme and a sensor of hydrogen peroxide-mediated signaling, potentially regulating intracellular hydrogen peroxide concentrations in growth factor and tumor necrosis factor-alpha signaling cascades (UniProt: P32119).

In Alzheimer's Disease, PRDX2 is downregulated in post-mortem brain tissue from AD patients compared to age-matched controls (Chaparral AD proteomics). The protein shows reduced abundance with a mean log2 fold-change of −0.394 across subcellular fractions in TMT-labeled quantitative proteomics analysis of human brain samples. This downregulation suggests diminished antioxidant capacity in the AD brain, potentially contributing to increased oxidative stress—a pathological hallmark of Alzheimer's Disease.