Peroxiredoxin-6

Peroxiredoxin-6 (PRDX6) is a 224-amino acid thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to protect cells against oxidative stress (UniProt: P30041). Beyond its antioxidant function, PRDX6 exhibits phospholipase activity and acyl-CoA-dependent lysophospholipid acyltransferase activity, enabling it to both detoxify peroxides and maintain phospholipid homeostasis through conversion of lysophosphatidylcholine to phosphatidylcholine (UniProt: P30041).

In Alzheimer's Disease, PRDX6 is upregulated in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). Quantitative proteomics analysis revealed a mean log2 fold-change of 0.56 across subcellular fractions, indicating elevated protein abundance in AD brain (Chaparral AD proteomics). This upregulation may reflect compensatory responses to oxidative stress and lipid peroxidation, both hallmark features of AD pathology.