14-3-3 protein theta

14-3-3 protein theta (YWHAQ) is an adapter protein that regulates signaling pathways through phosphoserine and phosphothreonine motif recognition on binding partners, thereby modulating their activity. It negatively regulates PDPK1 kinase activity (UniProt: P27348).

The protein is widely expressed and participates in diverse cellular signaling cascades across tissues. No monogenic disease associations are documented in UniProt for YWHAQ.

In Alzheimer's Disease, 14-3-3 protein theta shows ambiguous regulation across subcellular fractions in post-mortem AD brain compared to age-matched controls (Chaparral AD proteomics). The mean log2 fold-change is −0.0767, indicating minimal overall change, though direction varies by subcellular fraction in this TMT-labeled proteomics experiment (4 fractions analyzed). This modest and inconsistent signal suggests 14-3-3 theta is not a primary candidate for AD-related dysregulation.