protein
BAR/IMD domain-containing adapter protein 2
Gene
BAIAP2
Organism
Homo sapiens(9606)
Length
552 aa
Mass
60,868 Da
BAIAP2 (BAR/IMD domain-containing adapter protein 2) is a cytoplasmic adapter protein that links membrane-bound small G-proteins to effector proteins, playing a central role in actin cytoskeleton reorganization. It mediates CDC42- and RAC1-dependent cytoskeletal dynamics, facilitates filopodia formation in concert with ENAH and EPS8, and supports neurite growth and actin bundling (UniProt: Q9UQB8).
The protein functions broadly in cytoskeletal regulation across diverse cellular contexts, including neuronal morphogenesis and response to bacterial infection. No non-AD disease associations are currently annotated in UniProt for this entry.
BAIAP2 is downregulated in Alzheimer's disease brain tissue relative to age-matched controls (Chaparral AD proteomics), with a mean log2 fold-change of −0.98 across post-mortem samples analyzed by TMT-labeled quantitative proteomics. This reduction in cytoskeletal regulator abundance may reflect disrupted neuronal architecture or actin dynamics characteristic of AD pathology.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
not detected
P2
not detected
S2
-0.983
S3
not detected
Mean log₂FC across detected fractions: -0.9828 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions
Sources
Last updated 5/8/2026, 6:25:45 AM