14-3-3 protein beta/alpha

14-3-3 protein beta/alpha (YWHAB)

14-3-3 protein beta/alpha is an adapter protein that regulates diverse signaling pathways by binding phosphorylated partners, typically at phosphoserine or phosphothreonine motifs, and modulating their activity (UniProt: P31946). The protein functions as a negative regulator in multiple contexts, including suppression of osteogenesis and blockade of neuronal apoptosis through inhibition of SRPK2 nuclear translocation, as well as antagonism of MAP kinase activation cascades.

No tissue-specific expression details or non-AD disease associations are documented in the UniProt record for this protein.

14-3-3 beta/alpha shows downregulation in Alzheimer's disease. In human post-mortem AD brain tissue compared to age-matched controls, the protein was consistently reduced with a mean log2 fold-change of −1.16 across the analyzed subcellular fractions (Chaparral AD proteomics). This downregulation suggests potential impairment of signaling regulation and apoptosis protection in AD pathology, though the functional consequences require further investigation.