14-3-3 protein epsilon

14-3-3 protein epsilon (YWHAE) is an adapter protein that regulates diverse signaling pathways through phospho-motif recognition (UniProt: P62258). It modulates numerous binding partners by recognizing phosphoserine or phosphothreonine residues, influencing their activity. The protein plays roles in HSF1 nuclear export, antiviral signaling via RIGI-MAVS interaction, and cell cycle regulation through HNRNPC degradation.

14-3-3 epsilon is broadly expressed across tissues and participates in general and specialized signaling networks. No tissue-specific disease associations are documented in UniProt for this entry.

In Alzheimer's disease, this protein shows ambiguous regulation across subcellular fractions (Chaparral AD proteomics). Analysis of post-mortem AD brain versus age-matched controls using TMT-labeled, four-fraction proteomics detected a near-zero mean log2 fold-change of 0.026, suggesting minimal or inconsistent change across the P2, P3, S2, and S3 fractions. This pattern indicates the protein's abundance or distribution may vary unpredictably depending on subcellular compartment in AD pathology.