Elongation factor 1-gamma

Elongation factor 1-gamma (EF-1-gamma) is a translation-associated protein that probably plays a role in anchoring the eukaryotic elongation factor 1 complex to other cellular components (UniProt: P26641). It is a 437-amino acid protein with a molecular mass of approximately 50 kDa.

EF-1-gamma is a core component of the translation machinery, functioning as part of the elongation factor 1 complex involved in protein synthesis. No disease associations are documented in UniProt curated data.

EF-1-gamma is moderately upregulated in Alzheimer's disease brain tissue. Analysis of post-mortem AD brain compared to age-matched controls using TMT-labeled quantitative proteomics across four subcellular fractions identified EF-1-gamma as significantly elevated with a mean log2 fold-change of 0.85 (Chaparral AD proteomics). This upregulation may reflect compensatory responses or alterations in protein synthesis capacity within the AD brain.