Elongation factor 1-beta

Elongation factor 1-beta (EF-1-beta), encoded by EEF1B2, is a catalytic subunit of the guanine nucleotide exchange factor (GEF) within the eukaryotic elongation factor 1 (eEF1) complex (UniProt: P24534). It functions to stimulate the exchange of GDP for GTP on elongation factor 1A (eEF1A), facilitating nucleotide turnover critical for protein synthesis.

EF-1-beta is a core component of the translation initiation and elongation machinery, operating broadly across tissues where active protein synthesis occurs. No disease-specific associations are documented in the UniProt record.

In Alzheimer's Disease brain, EF-1-beta shows ambiguous regulation across subcellular fractions in post-mortem tissue from affected individuals compared to age-matched controls, with a mean log2 fold-change of 0.14 (Chaparral AD proteomics). This modest shift, measured across two fractions in TMT-labeled DDA proteomics analysis, does not indicate consistent up- or down-regulation and warrants validation in additional cohorts to clarify any disease relevance.