Isoform 3 of Clathrin light chain A

Clathrin light chain A (CLTA) isoform 3 is a 25.7 kDa protein that functions as a component of the clathrin coat, which mediates endocytosis and vesicular transport (UniProt: P09496-3). The protein localizes to subcellular compartments involved in membrane trafficking and is expressed across multiple tissues. No primary disease associations are documented in UniProt.

CLTA isoform 3 has been curated as relevant to Alzheimer's Disease. In quantitative proteomics analysis of post-mortem AD brain tissue compared to age-matched controls using TMT labeling and data-dependent acquisition across four subcellular fractions (P2, P3, S2, S3), the protein showed an ambiguous direction of change (Chaparral AD proteomics). The mean log2 fold-change was −0.2119, reflecting minimal overall abundance difference; however, the conflicting directionality across fractions suggests compartment-specific alterations in clathrin light chain levels in AD pathology that may relate to endosomal dysfunction or altered membrane trafficking associated with amyloid and tau processing.