EH domain-containing protein 2

EH domain-containing protein 2 (EHD2) is an ATP- and membrane-binding protein that regulates membrane trafficking and reorganization through ATP-dependent tubulation. It plays a key role in endocytic recycling between the plasma membrane and endosomes, and is required for proper translocation of cargo proteins including GLUT4 and FER1L5, as well as for myoblast fusion and caveolae dynamics (UniProt: Q9NZN4).

EHD2 is broadly involved in membrane trafficking pathways critical for cellular homeostasis. The protein localizes to multiple subcellular compartments involved in vesicular transport, consistent with its endosomal trafficking functions. UniProt currently reports no designated disease associations for EHD2.

In Alzheimer's disease, EHD2 shows elevated protein levels in post-mortem AD brain tissue compared to age-matched controls. Quantitative proteomics analysis across subcellular fractions detected upregulation with a mean log2 fold-change of 0.52 (Chaparral AD proteomics), suggesting increased expression or altered protein stability in the AD-affected brain. The functional relevance of this dysregulation to AD pathobiology remains to be established.