Epsin-2 Summary

Epsin-2 (EPN2) is a 641-amino-acid protein that plays a role in the formation of clathrin-coated invaginations and endocytosis (UniProt: O95208). It functions in the early stages of clathrin-mediated endocytic internalization, a fundamental cellular process for membrane trafficking and protein uptake.

The protein operates primarily in endocytic pathways that are active across multiple cell types, including neurons. While no specific disease associations are documented in UniProt, Epsin-2 belongs to the epsin family of clathrin adaptor proteins with established roles in synaptic vesicle recycling and membrane dynamics.

Epsin-2 is upregulated in post-mortem Alzheimer's disease brain tissue compared to age-matched controls (Chaparral AD proteomics). The mean log2 fold-change is 0.34, representing a modest increase detected across one subcellular fraction in TMT-labeled quantitative proteomics of four fractions (P2, P3, S2, S3). This upregulation may reflect compensatory enhancement of endocytic processes or altered membrane trafficking dynamics in AD pathology.