Stomatin

Stomatin (STOM) is a 288-amino acid protein that regulates ion channel activity and transmembrane ion transport, with demonstrated regulatory effects on ASIC2 and ASIC3 channel function (UniProt: P27105). These acid-sensing ion channels are involved in neuronal signaling and pH-dependent cellular processes, positioning stomatin at the intersection of ion homeostasis and neurophysiology.

Stomatin is widely expressed across tissues and mediates cellular responses to osmotic and ionic stress. The protein's involvement in ion transport makes it relevant to neuronal excitability and synaptic transmission. UniProt records no primary disease association for stomatin; however, its regulatory role in ion channel activity suggests potential relevance to neurological conditions characterized by altered ion homeostasis.

In Alzheimer's Disease, stomatin shows elevated expression in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). The protein was upregulated with a mean log2 fold-change of 0.4158 across analyzed subcellular fractions in human brain derived from TMT-labeled proteomics of four cellular compartments (P2, P3, S2, S3). This upregulation may reflect compensatory responses to AD-associated neuronal dysfunction or altered ion handling in degenerating brain tissue.