Protein PRRC2C

Protein PRRC2C is a 2,896-amino-acid protein required for efficient formation of stress granules, cytoplasmic assemblies that sequester mRNAs and proteins during cellular stress (UniProt: Q9Y520). Stress granule dynamics are implicated in neuronal homeostasis and protein quality control, processes relevant to neurodegenerative disease pathology.

PRRC2C shows increased abundance in Alzheimer's Disease brain tissue. In post-mortem AD brain compared to age-matched controls, PRRC2C was upregulated with a mean log2 fold-change of 0.78 (Chaparral AD proteomics), detected across a single subcellular fraction in TMT-labeled quantitative proteomics. This upregulation suggests a possible compensatory or pathological stress response in AD neuronal tissue, consistent with the known role of stress granules in managing proteotoxic stress associated with amyloid and tau pathology.