Serine/arginine-rich splicing factor 11

Serine/arginine-rich splicing factor 11 (SRSF11) is an RNA-binding protein involved in pre-mRNA splicing regulation (UniProt: Q05519). The protein functions as part of the SR protein family, which modulates alternative splicing patterns and influences gene expression at the post-transcriptional level. SRSF11 is a 484-amino-acid protein with a molecular mass of approximately 53.5 kDa.

SRSF11 is widely expressed across tissues and participates in fundamental RNA processing mechanisms. The UniProt record does not document disease associations for this protein in its primary annotation database.

In Alzheimer's disease, SRSF11 shows elevated expression in post-mortem AD brain tissue relative to age-matched controls (Chaparral AD proteomics). The protein was significantly upregulated with a mean log2 fold-change of 0.70 in human post-mortem AD brain analyzed via TMT-labeled quantitative proteomics across subcellular fractions. This upregulation may reflect altered splicing activity or compensatory RNA processing changes associated with AD pathology, though functional consequences remain to be determined.